Most of the default settings can simply be left alone. It is however, recommended that you do take a look at the Advanced Settings page. Here you can set various important settings, if required.
Use Burnfree should be set - it controls the burn, ensuring that the buffer never gets dangerously low (which reduces the quantity of bad burns).
You may wish to automatically erase re-writable disks.
The option Do not eject medium after write process is invaluable if your drive is one that cannot be closed quickly enough for Verify to happen.